fulvic acid studies and research



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Fulvic acid patents studies and research

US Patent No: 6,569,900: Fulvic acid salts, esters or derivatives thereof in pharmaceutical preparations are effective for treating inflammation, acne, exzema or bacterial or fungal or viral infections. These pharmaceutical preparations may be given either orally or topically in the form of a solution, paste, ointment, powder to humans or animals. Humic substances are ubiquitous in nature and arise from the decay of plant and animal residues in the environment (MacCarthe et al. 1990). These substances can be divided into humic acid, fulvic acid and human on the basis of the solubility in water as a function of pH. Fulvic acid is the fraction that is soluble in water under all pH conditions and is in general lower in molecular size and weight and lower in colour intensity than humic acids.

US Patent No: 6,558,712:  The difference between Shilajit-based fulvic acid (FAs) and alluvial soil-derived fulvic acids lies in the core structures of the fulvic acids (FAs) in these compositions. Shilajit-Fulvics contains 3,8-oxygenated dibenzo-.alpha.-pyrone as the core nucleus, which, upon repeated oxidation, and Michael addition reactions by nucleophile-containing oxygen, nitrogen and carbon ions, in association with various lipid moieties, produce a multiplayer micellar structure. In contrast, alluvial soil derived Fulvic Acids are composed essentially of aromatic hydroxy acids and polyphenols derived from phenolic oxidations. Both these Fulvics contain different metal ions, especially Fe, Co, Zn, Ca, etc., associated with the FAs. The metals in Shilajit-Fulvics acid are well-organized, multicentered, metal-ion associated products which, in the case of iron, maintains the metal in the reduced state and produce different iron-containing enzymes. Such trace ion-metal associations are not possible for soil-FAs because they have a much less organized heteropolycondensate structure whose micellar structure is irregular.

Another unique feature of Shileet-Fulvic Acids is that it is of endogenous origin produced by animal systems. These systems meet the essential need of bioavailability of trace metals and minerals, which serve as a carrier of essential nutrients in the living animal body. By contrast, soil-FAs, being exogenous in origin, do not contribute to those essential needs of animals.

Silajit Fulvics also contains oligomeric (di, tri, tetra) dibenzo-.alpha.-pyrones, which scavenge free radicals and free metal ions, to become a soft-spin radical. In contrast, soil-FAs contain only esters of phenolic acids which do not have the antioxidant activity possessed by Shilajit-FAs.

Significantly, acylated DBP, with a lipid chain, are present in Shilajit-FAs; these actives behave like a liposome (polymicellar structure) which can act as an efficient carrier molecule. The phenolic acid esters present in soil-FAs do not possess these characteristics.

Thus, in accordance with the invention, the purified fulvic acid carrier constituent of native Shilajit, without toxic components, and substantially without bioactive constituents in the voids of the carrier, is provided by a defined extraction procedure from native Shilajit.

The purified Shilajeet composition containing the purified fulvic acid carrier is obtained by an extraction procedure from native Shilajit rock exdudate, according to the following steps: (a) powdering native Shilajit exdudate and dissolving it in water as solvent, (b) filtering the mixture to remove insoluble substances, (c) evaporating water from the filtrate to obtain a brown viscous residue, (d) extracting the residue with a hot organic solvent, e.g. methanol, to obtain both a soluble fraction and an insoluble Shilajit-humic fraction, (e) adding dilute aqueous NaOH to the insoluble Shilajit-humic fraction to precipitate polymeric quinones, (f) acidifying the alkaline filtrate to a pH below about 3 to precipitate humic acids, leaving a brown acidic solution of fulvic acids, (g) fractionating the acidic solution by passing it over activated carbon to provide a solution of low-to-medium M.sub.w fulvic acids, (h) passing the fulvic acid solution through a H.sup.+ ion-exchange resin to concentrate the fulvic acids in solution, and (i) evaporating the solution. 

US Patent No: 6,558,712:  The present invention provides a method for extracting fulvic acid from complexes of humic substances. The fulvic acid extract is safe for human and animal consumption and for application to plant foliage. As a result of the extraction method, the fulvic acid extract further comprises calcium and may comprise magnesium. Several components of humic substances are believed to be especially beneficial, humic acid and fulvic acid. These are operationally defined in terms of their solubility. Humic acid is the fraction of humic substances that is not soluble in water under acidic conditions but is soluble in water under alkaline conditions. Fulvic acid comprises the fraction of humic substances that is soluble under all pH conditions.

It is believed that because fulvic acid molecules are of a relatively small size, they are more readily absorbed by plants and can carry trace minerals from plant surfaces into plant tissues. Therefore, fulvic acids may be sprayed onto plants to maximize the productive capacity of plants. Fulvic acid is also believed to be of benefit to humans and may be taken orally in liquid form. 

Other independent research papers and studies on Fulvic acid

1. Hospital studies in China show that elderly patients, ages 60-90, when treated with fulvic 
acid, regained appetite, slept better, and became more energetic. Other hospital studies 

coming from India show that fulvic acids are considered to be a powerful anti-aging 
therapy that also able to help with symptoms of dementia. Erchuan Wang et al, Humic acid, 3 (1991)

2. Dr. Visser stated that with respect to internal use, humic and fulvic acids have been shown to be particularly useful in the prophylaxis (prevention), therapy and metaphylaxis (after-care) of a variety of stomach and intestinal troubles such as, hyper-acidity, diarrhea, gastric ulcers, dysentery, gastroenteritis and colitis. They can also act as a detoxifying agent, and have been used against bacterial and viral infections. They have been found to be useful in the treatment of anemia (deficiency of red blood cells, hemoglobin or total blood volume) and as a stimulator of the body.s immune system and of detoxifying liver functions. By counteracting certain kinds of cancerous growth, humic acids may also have a potential as an anti-carcinogen. Many of these effects can be attributed to the activity of humic and fulvic acids by themselves, and are the result of their surface activity, chelating properties, power of absorption, their polyacidic nature, their polyphenolic structure, their interaction with other organic molecules including polysaccharides, proteins, enzymes and lipids, as well as of their redox properties and fee radical content. No unfavorable side effects have so far been noticed with the administrationof humic or fulvic acids.

3. Studies of patients with gastric and duodenal ulcers showed that 91.1% had condition improve when treated with fulvic acid. Treatment showed no side effects, substantially diminished pain, with few relapses, with 61.1% of patients being completely cured.
Xinsheng Zhu, Fulvic Acid, 9 (1991)

4. Hospital patients with rheumatoid arthritis had 92% success rate when treated with humic extract baths. Yuan, Shenyuan; Fulvic Acid, 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June 1993

5. Clinical medical studies using humic and fulvic acids were performed on thousands of hemorrhoid patients, which were so successful that the Chinese government had a special pharmaceutical preparation developed for treatment of this condition. Yuan, Shenyuan; Fulvic Acid, 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June 1993


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